I.М. Antonyan, I.V. Volchik, E.A. Omeltchenko

The use of cell therapy methods for correction of copulatory behavior of experimental animals

Demographic characteristics of Ukraine and European countries demonstrate the high incidence of infertile marriages, with male factor emerging in half the instances. One of the many reasons that cause the development of male infertility is the reduction of testosterone secretion by the testes. The introduction of the diagnosis of “secondary hypogonadism” at the end of the 20th century occurred at the same time as the rapid increase of life expectancy, which explains the urgency of the problem for many millions of the male population. The standard treatment is testosterone replacement pharmacotherapy.

Our study investigated the ways of use of BMSCs for correction of copulatory changes developing in animals with experimental hormone deficiency. The results of unilateral BMSCs intratesticular injection of 80 000, 100 000 and 200 000 cells in the animal groups of cadmium hypogonadism model were subjected to a comparative evaluation.