A.V. Rudenko, S.P. Pasiechnikov, O.V. Romashchenko, P.O. Samchuk, L.F. Yakovenko

The influence of menstrual cycle on the immune status of women of reproductive age with acute uncomplicated pyelonephritis in combination with inflammatory diseases of genitals

In this work we presents the results of the study of local and systemic immunity in 90 women of reproductive age with acute uncomplicated pyelonephritis in combination with inflammatory diseases of the pelvic organs, including the period and duration of the menstrual cycle.

The obtained results allow to say that changes in local immunity play a significant role in the occurrence of acute pyelonephritis, which forms against the background of chronic pelvic inflammatory diseases in the period from the 20th to the 5th day of the menstrual cycle reliably predicting the adverse course of acute uncomplicated pyelonephritis. This provides an opportunity to re-evaluate the principles of prevention of this disease in women of reproductive age, and also timely and justified to prescribe antirecurrent courses of antibacterial and immunocorrective therapy. This approach will enhance the effect of antirecurrent therapy, and to reduce socio-economic losses associated with the treatment and rehabilitation of women of reproductive age.