A.V. Sakalo, I.S. Korenkova

Salvage therapy progressive testicularseminoma

Results of salvage therapy in 31 patients of testicular seminoma was studied. In all patients are diagnosed progression after chemotherapy based on platinum. Due to quality modes of salvage therapy used first-line chemotherapy regimens for 4 courses PIE, 4TIP and high doses (HDCE) carboplatin + etoposide.Results of predictive models of probability of progression and survival by binary logistic regression and based on the Kaplan-Mayer curves. Asa prognostic factors are considered: the age of patients, HGT and LDH level before the chemotherapy, chemotherapy mode first line to progression, extra gonadal presence of primary lesions, preliminary radio therapy, stage of disease at the time of diagnosis, of tumor response to first-line chemotherapy and duration of remission, prevalence at the start of the process salvage therapy. Results: 14 progressions diagnosed after 11 (3-23) months, died 9 (29%) patients in theperiod of 17.7 (8-29) months. Overall survivaland disease-free 3 years is 71% and 54.8% medium toxicity. Statistic importency of progression prognosis had only model for the predictor of duration of stabilisation or partial regression after first-line chemotherapy (p=0.002). Established improve survival when used 4 courses TIP and HDCE and compare dusing 4 courses PIE.