N.O. Pertseva

Changes of renal function and plasma lipids and in patients with type 2 diabetes mellitus with poor glycemic control during 1 year of angiotensin ii receptor antagonists therapy for arterial hypertension

The purpose of this study was to determine the dynamics of changes in the degree of nephropathic and dyslipidemic disorders in patients with a poor compensation for type 2 diabetes mellitus and hypertension in the correction of blood pressure using angiotensin II receptor antagonists for 1 year. 78 patients with type 2 diabetes with poor glycemic control (women - 65, men - 13) ware examined and treated for arterial hypertension during 1 year. Albuminuria was significantly higher in patients with type 2 diabetes than in the control group, but after receiving angiotensin II medication for arterial hypertension over 1 year most patients showed deterrent effect of therapy on the development of nephropathy. In patients with type 2 diabetes mellitus and hypertension with poor compensation of hyperglycemia adequate hypoglycemic therapy beside standard treatment of hypertension for 1 year lets cause regression of microalbuminuria in 18.6% of patients, along with the continuing severe degree of nephropathic and dyslipidemic disorders. Hypoglycemic therapy in patients with type 2 diabetes mellitus with poor control, receiving angiotensin II receptor antagonists for the treatment of hypertension, accompanied by regression of microalbuminuria in 23.3% of patients. Within 1 year of treatment in this group of patients there is a stabilization of lipidemic profile indicators.