S.A. Borisov, F.I. Kostyev, A.V. Borisov

The role of carbohydrate-protein metabolism products during acute pyelonephritis with concomitant diabetes mellitus in an experiment

The results of experimental work on rats are analyzed in the study, by determining the possibilities for correcting the level of glycosylation products and the state of the functional ability of proteins at an early stage of the infectious inflammatory process in the kidneys. The intensity of the formation of methylglyoxal in acute pyelonephritis complicated by concomitant diabetes is due to the development of oxidative stress, which is confirmed by an increase in the level of protein carbonyl groups in the tissues studied. The presented data allow deeper to lower the features of the pathogenetic mechanisms underlying the development and course of acute pyelonephritis complicated by diabetes mellitus, and the use of multivector drug products reduced the severity of pathological abnormalities in blood and kidney tissues to a greater extent in diabetes mellitus type II, which creates conditions to improve the morphofunctional state of the kidneys.