A. Havrylyuk, V. Chopyak, Y. Nakonechnyy, M. Kamieniczna, M. Kurpisz

The antispermal antibodies in different groups of infertile men

Infertility is defined as inability of couples to achieve pregnancy following the one year of unprotected intercourse. By this criterion, infertility affects 13-18% of couples. The male factor accounts for up to half of all the cases. The incidence of infertility in men is still difficult to establish, however current evidence suggests that up to 20-25% of young men have poor semen. Male reproductive tract infection and inflammation are important aetiological factors of infertility. The status of immune system and the presence of antispermal antibody are associated with infertility too. No cause of infertility can be found using routine diagnostic work-up in 10-15% of couples.

The aims of this work were - to detect the levels, classes and topography of antispermal antibodies in control group of healthy men and in different groups of infertile men; to prove or to abolish the immunological reason of infertility in different groups of infertile men.

Observations were carried out in a group of 100 men (27 - healthy controls and 73 - with infertility). The levels, classes and topography of antispermal antibodies were determined in seminal plasma and blood serum by using indirect immunobead test - IDIBT.

We have found statistically significant differences between control group and groups of infertile patients with somatic pathology, idiophatic infertility and men with early miscarriage in wives in levels of antispermal antibodies classes IgG and IgA in seminal plasma. Also we have found statistically significant differences between control group and groups of infertile patients with autoimmune diseases, idiophatic infertility and men with early miscarriage in wives in levels of antispermal antibodies classes IgG, IgA and IgM in blood serum. The results obtained in a control group, group of patients with autoimmune diseases and a group with anatomical disturbances indicated the topography of antispermal antibodies named Tt. The results obtained in a group of patients with somatic pathology, idiopathic infertility and men with early miscarriage in wives indicated the topography of antispermal antibodies named H, T and Tt. These findings (especially in semen plasma) may indicate a big concern of the risk of formation of immunodepending infertility in the males with somatic pathology, idiopathic infertility and men with early miscarriage in wives.