L.P. Sarychev, A.L. Pustovoyt

Role of bacterial translocation from the colon inthe pathogenesis of bacteriuria

Article focuses on the role of bacterial translocation from the colon as the missing link in the chain of pathogenesis of bacteriuria. A bacteriological study of flora and direct microscopy of kidney and colon biopsy samples in 30 subjects, who during their lifetime had no kidney diseases, was performed. Isolation of identical uropathogens from the kidney and colon in «conditionally healthy people» confirms the existence of bacterial translocation from the colon as a physiological process that occurs throughout life, increasing with age. Under conditions of stress, dysbiosis, for other reasons, reduced functionality in barrier function of colon and increase of passage of bacteria to the blood stream are followed by elimination them by kidneys. In this case, the violation of evacuation of urine and adhesion of coliform bacteria to urothelium become a condition to persistence of urinary infection.