Y.M. Dekhtiar, F.I. Kostev, V.V. Budiyanska

Differential pharmacotherapy of dysuric symptoms depending on the clinical features of an overactive bladder

The aim of the study was to determine the differentiated approach to drug therapy in patients with overactive bladder (OAB), depending on the clinical features of the disease. The study involved 87 women with lower urinary tract symptoms, the appropriate criteria for the diagnosis of OAB. It was found that the pathogenic effect of the antidepressant Mirtazapine therapy in combination with an anticonvulsant Gabapentin in treatment of OAB is to optimized the reservoir and evacuation function of the bladder. Combination therapy m-anticholinergic Tolterodine and Mirtazapine helps to restore control of urination and an increase in the absolute and relative volume of the bladder, significantly improves urination, without giving rise to obstructive voiding. The study showed the effectiveness of a combination of Gabapentin and Phenibut the treatment of OAB with algic syndrome that marked the end of 6 weeks of cystalgia intensity decrease of 62%.