G.G. Khareba, A.N. Dubinina

Chemotherapy plus hormonal therapy for treatment of new diagnosed prostate cancer

In the article we study a combination of chemotherapy and hormone therapy as a new method of treatment for patients with new diagnosed locally advanced or metastatic prostate cancer.

We have analyzed the results of treatment of 41 patients with new diagnosed locally advanced and metastatic prostate cancer with a poor prognosis: Gleason score of 8 points or more, the stage rT3v, pT4, the presence of visceral or ³ 4 lesions of bone metastases.

The first group (24 patients) received anticancer treatment with: mitoxantrone (12 mg/m2 every 21 days intravenously) / prednisolone 5 mg/day + androgen deprivation. The second group (17 patients) received only androgen ablation.

Intermediate results based on the dynamics of PSA and level of quality of life and analysis of toxicity of treatment show the high efficiency of the method, the need for further research and deeper analysis of the data. The degree of toxicity of the proposed method is acceptable. This determines the possibility of wide application of such treatment approach.