A.V. Sakalo

Treatment of disseminated stages of seminoma

We performed analysis of treatment results in 27 patients with Stage IIC-IIIC disseminated seminoma, prognostic factors, described prognostic models built by means of binary logistic regression, offered modification of treatment in patients with poor somatic status in order to reduce the incidence of tromboembolic complication, analysis of Kaplan-Meier curves.

5-years cancer-specific survival after first-line chemotherapy in patients with disseminated seminoma of testis was 85,2%, which corresponded with intermediate prognosis according to IGCCCG criteria and featured moderate toxicity. Four cycles of PEB is a first line treatment, radiotherapy is a reserved treatment option.

Multivariate analysis revealed that T stage is the only unfavourable prognostic feature which affects survival.

Administration of carboplatinum (AUC-4, 3-5 cycles) prior to chemotherapy 4РЕВ prevents thromboembolic complications and syndrome of acute lysys of tumor.