T.O. Pertseva, M.K. Rokutova, E.I. Tadgieva
The influence of cardiovascular risk factors on glomerular filtration rate in young patients with abdominal obesity
In the article the estimation results of the influence abdominal obesity and cardiovascular risk factors on glomerular filtration rate (GFR) in young persons with abdominal obesity are presented. 53 patients are inspected from age 18 by 40 with abdominal obesity, I-III (in obedience to classification of IDF, 2005). As a result of undertaken studies it is shown that this category of patients has high-frequency of basic cardiovascular risk factors: the positive inherited anamnesis on obesity and hypertension, mainly on a maternal line, smoking, hypertension 1 degree, impaired fasting glucose, impaired glucose tolerance, dyslipidemia, hyperinsulinemia, insulin resistance, and also hyperleptinemia. It is necessary to underline that reliable direct influence of abdominal obesity, smoking and associated metabolic displays on GFR takes place. It should be noted that persons with abdominal obesity and hypertension 1 degree have a synergetics effect of influence on a renal function actually abdominal obesity and hypertension. Thus, the necessity of exposure basic cardiovascular risk factors for the increase of diagnostics and treatment early obesity-association glomerular displays in this category of patients is shown.