E. Lytvynets, N. Scoropad

Oxidative stress and antioxidant defenses in patients with the urolithiasis

The article presents the results of research of indicators of oxidative modification of proteins and antioxidant enzymes in patients with the urolithiasis. The study involved 76 patients aged 18 to 65 years, patients with the urolithiasis. The first of group was 56 patients with the urolithiasis and the second - 20 healthy. We found the patients have a prooxidant activation, which is manifested by a significant increase of the level of oxidation-modified proteins. Thus, the rate of oxidative modification of proteins OMP-356, reaching (0,295±0,0060) compared with patients of healthy group (pN<0,05). The maximum value of the OMP-370 and OMP-430 were registered in the group of patients with urolithiasis (pN <0,05). Content of OMP-530 in patients with the urolithiasis with practically wasn’t different from the rate of the control group, and compared with healthy (pN<0,05). However, in these patients was diminished the antioxidant protection, confirming a significant reduction in enzyme activity of superoxide dismutase and especially catalase.