R.N. Molchanov, I.S. Shpon’ka

Infiltrations of the bladder tumor with immune cells at the accompanying infection of urinary ways

It is supposed that the accompanying urinary infection can influence the local immunity activity, leading to changes of features of bladder cancer course. A research objective was studying of the urinary tract infection influence on an infiltration of a tumor with immune cells. Immunohistochemical research of an expression of markers CD3 +, CD4 +, CD8 +, CD20 +, CD68 + in biopsy material, received from 44 patients with a bladder cancer was made. The patients were divided on two groups in conformity with absence or presence of urinary tract infection. It is established that T-cells are prevailing among immunocytes, infiltrating a superficial bladder cancer. In stromal compartment prevail СD4 +, while in epithelial - СD8 + T-lymphocytes and СD68 + macrophages. The accompanying urinary tract infection had no statistically significant influence on intensity and selectivity of infiltration of a tissue of tumor with СD3 +, СD4 +, CD8 +, СD68 + immunocytes. The significant augmentation of infiltration of the stromal compartment of tumor with СD20 + B-lymphocytes with formation of lymphatic follicles in patients with urinary tract infection, can be an element of a chronic interstitial inflammation.