N.O. Pertseva, D.I. Chub

Early diagnosis of progressing of diabetic nephropathy in patients with diabetes 1 type using clinical and laboratory indicators

The aim of the study was to determine the general clinical indicators of early diagnosis of the progression of diabetic nephropathy in patients with DM1T by studying the relationship between a set of clinical and laboratory parameters which characterize the kidney function and the lipid profile.

A survey of 136 patients with DM1T was performed in the endocrinology department of the «Clinic of the Medical Academy», Dnipro in 2016-2017. The control group consisted of 20 practically healthy persons. Clinical laboratory examination included: general blood analysis, general urine analysis, lipid profile-total cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL), triglycerides (TG), blood creatinine level, level of albuminuria (AU). The glomerular filtration rate (GFR) was calculated using the formula CKD-EPI.

The results of the study revealed a direct correlation between AU and GFR, which gives reason to consider the level of AU as an important marker of the progression of DN. Analysis of correlation relationships in subgroups of patients with DM1T found that the lipid profile of the blood had medium strength feedbacks with a GFR score. Therefore, the detection of elevated lipid profile indices in patients with diabetes mellitus may indicate a progression of DN. The regression model obtained in the study can be used to predict the GFR score in patients with diabetes.