Suvaryan A.L.
A role of central nervous system in development of infertility in patients with varicocele
Varicocele has not only medical but also of great social importance, since a negative effect on spermatogenesis and leads to male infertility. Mechanisms for the development of varicocele, which lead to progressive deterioration of spermatogenic, and further, the hormonal function of the testes is still unknown. Different hypotheses have been proposed to explain testicular damage in varicocele: an increase in temperature, increase or decrease in testicular blood flow, reflux and toxic effects of metabolites kidney or adrenal gland, hypoxia, and hormonal disorders, autoimmune defects, akrosomalnye reactions, oxidative stress and apoptosis - are just some of the factors that affect the pathophysiology of varicocele. However, today there is no information about the manner in which the development of varicocele affects the central nervous system - particularly in the hypothalamic - pituitary system, as the main regulator of spermatogenesis and testosterone production. What is the role of the CNS in the development of pathospermia and infertility? We have investigated the astroglial activity in some parts of the brain in experimental varicocele in rats. Reduced testosterone levels in the blood of rats under the condition of the experimental varicocele leads to an increase in the number of S - 100b in the brain that may cause depolymerization of filament shape GFSF, and hence an increase in the soluble form of the same protein in hormone - sensitive brain regions (especially in the thalamus - hypothalamus, and cerebellum). Violations in the CNS may affect spermatogenesis and testosterone production. Problem needs further study.