A.V. Sakalo, S.V. Bazalitskaya, Yu.M. Bondarenko, V.V. Mrachkovskiy, L.M. Zahartseva, V.S. Nedelchev, S.V. Cheremuha

Prognostic value of p53 and bcl-2 in patients with germ cell tumors of the testis in the dynamics of disease progression and chemotherapy

The aim of the work was to study the predictive value of markers of apoptosis p53 and bcl-2 in patients with testicular germ cell tumors (GCT). The expression of molecular genes p53 and bcl-2 in primary tumor was investigated by immuno­histochemistry in 40 patients with GCT depending on the stage, weight and phenotype of tumor as well as results of chemotherapy. The increased expres­sion of p53 was found in 35 (87.5%), bcl-2 in 9 (22.5%) patients. Relationship were not detected between stage of the process, tumor size and expres­sion of the studied genes. Close relationships (p<0.001) between the degree of expression of p53 can be used to predict the effectiveness of chemo­therapy.