S.O. Vozianov,V.S. Sakalo, Z.V. Gatserelia, V.V. Mrachkovskyi, A.V. Sakalo, Yu.Yu. Kuranov, A.V. Kondratenko, P.M. Salii, Ya.V. Levchyshyn, B.M. Navrotskyi

Organ-sparing multimodality treatment in muscle-invasive bladder cancer

Goal. Improving short- and long-term cancer outcomes, quality of life, and reduce complication rate after treatment of patients with muscle-invasive bladder cancer by justifying the indications for organ-sparing surgery with adjuvant chemotherapy.

Materials and methods. A retrospective analysis of 120 patients who underwent organ-sparing surgery was performed. Patients were divided into 3 groups. In the comparative analysis of the studied groups, the assessment of oncological results, quality of life and postoperative complications

Results. Patients who underwent partial cystectomy of bladder with adjuvant chemotherapy, showed better in comparison to two other groups remote oncological results by 20%. The mean follow-up was 6 years. The evaluation of oncological results was performed due to the guidelines of the European Association of Urology for patients with MIBC after organ-preserving multimodality treatment. Indicators of erectile function and quality of life in the main group were better than in two other groups.

Conclusions. The presented results of the study suggest that organ-preserving treatment with chemo-radiation therapy of muscle-invasive bladder cancer is an alternative method of treatment.