R.N. Molchanov, I.S. Spon’ka, V.N. Sliusarev
Influence of A-bacterinum on local immunity in patients with superficial bladder cancer
Probiotics are perspective preparations for adjuvant therapies at patients with transitional cell bladder cancer. Features of their influence on local immunity are scantily known.
Research objective was studying the effect of probiotic A-bacterinum, which contains Aerococcus viridans 167 strain, on the state of local immunity in bladder cancer patients.
Materials and methods. Immunohistochemical (IHC) study of CD3, CD4, CD8, CD20, CD68 expression in bioptates, taken from 20 superficial bladder cancer patients after single probiotic Abacterinum intravesical instillation was done. Results were compared against the data of 44 bladder cancer patients who were divided into two groups accordance to presence of concomitant urinary tract infection.
Results and conclusions. After probiotic instillation the immunocell tumor infiltration found to be lower as compared with other groups. Expression intensity of СD3, СD4, and CD8 in all studied groups had no statistically significant difference. In patients of A-bacterinum group an intensity of СD20 and СD68 markers expression was lower as compared with a group with concomitant UTI. Thus, A-bacterinum, like other probiotics has modulation properties on local immunity of urinary bladder, reducing an inflammatory answer and lowering immunocell infiltration.