O.V. Lyulko, R.N. Molchanov, I.S. Shpon’ka
Evaluation of cell cycle and intercellular adhesion markers expression in bladder cancer patients
Objective was to reveal the presence of relations between expression of CD95, p53, Ki-67, Bcl-2, BAX, E-cadherin and .-catenin markers and clinicopathological characteristics of superficial bladder cancer and presence of accompanying urinary tract infection.
Materials and methods. Immunohistochemical study of expression mentioned above markers in byoptates taken from 44 superficial bladder cancer patients who were divided into groups according to absence or presence of concomitant urinary tract infection.
Results and conclusions. Statistically significant increase of markers p53, Ki67 and decrease СD95, BAX, E-cadherin and .-catenin expression in tumor tissue as against the control was found. That testifies to decrease apoptotic activity and adhesive properties, increase of proliferation of urothelium.
We have not revealed statistically significant distinctions of the investigated markers expression at comparison of groups of bladder cancer patients with or without urinary tract infection.
Presence of direct b connectivity between p53 and Ki-67, bcl-2 and BAX (P .0.000001) expression in I group; Ki-67 and bcl-2 (P <0.000001), bcl-2 and BAX (P =0.000220), bcl-2 and .-catenin (P =0.000131) expression in II group can testify about changing of the investigated factors' interaction and, perhaps, course of tumoral development against the background of inflammatory process.