Yu.O. Mytsyk, Yu.B. Borys, I.Yu. Dutka, I.M. Komnatska, R.M. Lozynsky, I.S. Shatynska-Mytsyk

Application of the diffusion-weighted MRI for the diagnostics of the renal cell carcinoma with different pathological grades

Renal cell carcinoma (RCC) is the most common malignant epithelial tumor of the kidney, accounting for 85-90% of all solid renal tumors in adults and comprising 1-3% of all malignant visceral neoplasms. The study included 62 adult patients with pathologically verified clear cell subtype of the renal cell carcinoma (ccRCC) and15healthy volunteers. All patients underwent renal MR imaging which included diffusion-weighted imaging (DWI) with subsequent apparent diffusion coefficient measurement (ADC). In the result of the clinical trial we observed significant difference in mean ADC value of the normal renal parenchyma and ccRCC - 1,82 ± 0,16  10- 3 mm2/s vs 2,15 ± 0,12  10- 3 mm2/s correspondingly (р < 0,05). Also statistically reliable difference in ADC values in patients with high and low ccRCC grades was obtained