A.V. Sakalo

Alternative treatment scheme of seminoma for carboplatin, etoposide and bleomycin (CEB)

Testicular germ cell tumors are highly sensitive to the chemotherapy, the standard treatment for seminoma stages II-III is 3PEB/4PE, treatment is associated with acute and delayed toxicity. Results of treatment of 17 patients under the scheme CEB (carboplatin AUC=5, etoposide 100 mg/m2in 1-5 days and bleomycin 30 mg on day 2).

3 years OS and DFS after 4CEBis 94,1% and 88,2% respectively, with less toxicity (associated with cisplatin to carboplatin replacement and bleomycin dose reduction to 30 mg). Preliminary results of the treatment with scheme 4CEB seminoma stage II-III can be considered as an alternative to the standard scheme.